The murine excisional wound model: Contraction revisited
نویسندگان
چکیده
منابع مشابه
Silicone ring implantation in an excisional murine wound model.
UNLABELLED A good animal model for wound healing is indispensable for researchers to study the basic mechanism of tissue repair, and to develop strategies for clinical treatment. Small mammalian wound healing models are the most popular animal models for wound healing research because they are inexpensive, readily obtainable, and easy to handle. One significant challenge of using mice to evalua...
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The response to major burn injury includes systemic release of mediators that may have an effect on wound healing. The authors evaluated the effect of a burn injury on the contraction of an excisional wound adjacent to the burn, and the effect of plasma derived from burn-injured animals on the contraction of the fibroblast-populated collagen matrix (FPCM). Nine rats (90-100 days old) under anes...
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BACKGROUND Texture, color, and durability are important characteristics to consider for skin replacement in conspicuous and/or mobile regions of the body such as the face, neck, and hands. Although autograft thickness is a known determinant of skin quality, few studies have correlated the subjective and objective characters of skin graft healing with their associated morphologic and cellular pr...
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BACKGROUND Approximately 15% of the United States population suffers from chronic kidney disease (CKD), often demonstrating an associated impairment in wound healing. This study outlines the development of a surgical murine model of CKD in order to investigate the mechanisms underlying this impairment. METHODS CKD was induced in mice by partial cauterization of one kidney cortex and contralat...
متن کاملMechanistic Model of Wound Contraction
geometry. !& 1993 Academic Press, lnc. ing and inflammation, then a rational basis for the design and application ofpharmacologic modulators of cell behavior to augment or mitigate wound contraction (as appropriate for the nature of the wound being managed) would be available. The model proposed here is a first attempt in that direction. A preponderance of evidence implicates fibroblastic cells...
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ژورنال
عنوان ژورنال: Wound Repair and Regeneration
سال: 2015
ISSN: 1067-1927
DOI: 10.1111/wrr.12338